i had checked but it not responding
let me know which environment you are using so based on that I will let you know about exact answer.
In development environment no need to do any command like supervisor. Pyc files generate base don your request.
for me, I ran the following commands to resolve the issue.
$ bench --site mysite.com --migrate
$ bench --site all clear-cache
$ sudo supervisorctl reload
$ sudo service nginx restart