Hi everyone,
I’m Emmanuel Katto from Dubai, United Arab Emirates (UAE) working on screening 16 categorical factors (representing 16 different genes that I’m activating), but I’m facing a challenge. The total amount of DNA I can deliver is limited, so activating more than 8 genes per run leads to weaker activation, making it difficult to interpret the results. I need a way to limit the number of factors to 8 per run, but still capture the main effects and some 2-factor interactions (2FI) across all 16 genes.
Has anyone encountered this issue in a DOE design? Any strategies or approaches to achieve this would be greatly appreciated!
Thanks!
Regards
Emmanuel Katto