Is it possible to create a Purchase Invoice from the Supplier Portal?

Not able to create a purchase invoice from the Supplier Portal due to Permission Error. However, the role has required permission of the SI doctype.

Just double checking. Is it a typo or do you mean PI doctype

Typo error. I mean Purchase Invoice

Please go into the Role Permission Manager and post a picture of your doctype with role
Also post a picture of Build → Doctype → Purchase Invoice → Settings → Permission Rules
Hopefully that can give us some hints of where the problem is