POS and warehouse of stock

Dear communities :
I set two companies as well as POS profile in my system.
I want to know if I can ignore the default warehouse of the item,and whenever I use POS system,it will search the warehouse I have set in POS profile.
Or it will be strange in logic that I can’t adjust warehouse of my item according to my company user.
thanks

I want to know if I can ignore the default warehouse of the item, and whenever I use POS system,it will search the warehouse I have set in POS profile.

If left blank in the POS Setting, it will fetch values from Item master.

Or it will be strange in logic that I can’t adjust warehouse of my item according to my company user.

You can define default Warehouse for the user from User Permissions feature.

https://frappe.github.io/erpnext/user/manual/en/setting-up/users-and-permissions/user-permissions