Problem in apache erpnext

[Sun Sep 05 13:57:32.694838 2021] [proxy:error] [pid 5759] (111)Connection refused: AH00957: HTTP: attempt to connect to (localhost) failed
[Sun Sep 05 13:57:32.694861 2021] [proxy_http:error] [pid 5759] [client x.x.x.x:50743] AH01114: HTTP: failed to make connection to backend: localhost, referer: http://x.x.x.x/desk
this error repeated many and many every seconds at error_log for apache due to server down after few hours