I had an issue with Nginx with the Safari Browser, after install let’s encript SSL certificate, erpnext only worked in Chrome and Firefox but Safari did not, and after a long time seaching, I found the solution here.
https://cnedelcu.blogspot.com/2016/07/nginx-and-letsencrypt-ssl-certificate-safari-ios-problem.html
We just have to set up the nginx.conf file, in the frappe-bench/config folder with server block with ssl_session_cache shared:SSL:10m;
and restart nginx and worked.!
I hope this is useful for someone in the future.